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80 In a recent meta-analysis, MTX showed a substantial clinical and statistically significant benefit compared to a placebo in the short-term treatment of people with RA, although its use was associated with a 16% discontinuation rate due to adverse side effects

Conclusion This novel study in youth with type 2 diabetes demonstrated that short-term metformin improved postprandial blood glucose levels and was associated with modest increases in incretin concentrations in the absence of changes in rates of glucose production and gluconeogenesis

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